What Are Coleus Good For
Edward R. Forte
October 24, 2021
View abstract.Bartels, S. P., Lee, S. R., and Neufeld, A. H.
The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits.View abstract.View abstract.View abstract.View abstract.View abstract.View abstract.View abstract.View abstract.Ding, X. and Staudinger, J.
L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway.J Pharmacol Exp Ther 2005;312(2):849-856.View abstract.View abstract.A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release.Cell Biol Int 2006;30(11):940-946.Lindner, E., Dohadwalla, A. N., and Bhattacharya, B.
K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin.Marone, G., Columbo, M., Triggiani, M., Cirillo, R., Genovese, A., and Formisano, S. Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin.Matsumoto, S., Yamashita, T., Araie, M., Kametani, S., Hosokawa, T., and Takase, M.
The ocular penetration of topical forskolin and its effects on intraocular pressure, aqueous flow rate and cyclic AMP level in the rabbit eye.Basic Res Cardiol 1989;84 Suppl 1:197-212.Shen, Y. H. and Xu, Y.
L. Two new diterpenoids from Coleus forskohlii.[Studies on the chemical constituents in root of Coleus forskohlii].Yang, Q.
R., Wu, H. Z., Wang, X. M., Zou, G. A., and Liu, Y.
W. Three new diterpenoids from Coleus forskohlii Briq.Agarwal KC, Parks RE.Forskolin: a potential antimetastatic agent.Int J Cancer 1983;32:801-4.Agarwal KC, Zielinski BA, Maitra RS.Clin Pharmacol Ther 1993;53:76-83.Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy.Arch Ophthalmol 1987;105:637-41.Burstein NL, Sears ML, Mead A. Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator.Exp Eye Res 1984;39:745-9.Caprioli J, Sears M, Bausher L, et al. Forskolin lowers intraocular pressure by reducing aqueous inflow.Invest Ophthalmol Vis Sci 1984;25:268-77.Caprioli J, Sears M. Forskolin lowers intraocular pressure in rabbits, monkeys, and man.The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release.J Int Med Res.J Int Med Res.Clinical efficacy of Coleus forskohlii (Willd.).Loftus HL, Astell KJ, Mathai ML, et al.
Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial.Meyer BH, Stulting AA, Muller FO, et al.The effects of forskolin eye drops on intra-ocular pressure.Nebbioso M, Belcaro G, Librando A, et al. Forskolin and rutin prevent intraocular pressure spikes after Nd:YAG laser iridotomy.Nebbioso M, Rusciano D, Pucci B, et al.Eur Rev Med Pharmacol Sci.Forskolin: a unique diterpene activator of cyclic AMP-generating systems.J Cyclic Nucleotide Res 1981;7:201-24.Tzanakakis GN, Agarwal KC, Vezeridis MP.
COLEUS: Overview, Uses, Side Effects, Precautions, Interactions
Ahmad, F., Khan, M. M., Rastogi, A. K., and Kidwai, J. R. Insulin and glucagon releasing activity of coleonol (forskolin) and its effect on blood glucose level in normal and alloxan diabetic rats.Bartels, S. P., Lee, S.
R., and Neufeld, A. H. The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits.Battochio, A. P., Sartori, M.
S., and Coelho, C. A.
Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats.Bersudsky, Y., Kotler, M., Shifrin, M., and Belmaker, R. H.
A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients.Cahn, D., Melman, A., Valcic, M., and Christ, G. J.
Forskolin: a promising new adjunct to intracavernous pharmacotherapy.Caprioli, J., Sears, M., Mead, A., Kosley, R. W., Jr., Cherill, R.
J., Hugher, F. P., Allen, R. C., and Tressler, C. Adenylate cyclase stimulation and intraocular pressure reduction by forskolin analogs.Damanik, R., Wahlqvist, M.
L., and Wattanapenpaiboon, N. Lactagogue effects of Torbangun, a Bataknese traditional cuisine.Ding, X. and Staudinger, J.
L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway.Dubey, M.
P., Srimal, R. C., Nityanand, S., and Dhawan, B.
N. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii.Ealey, P.
A., Kohn, L. D., Marshall, N. J., and Ekins, R.
P. Forskolin stimulation of naphthylamidase in guinea pig thyroid sections detected with a cytochemical bioassay.Han, L.
K., Morimoto, C., Yu, R. H., and Okuda, H.
Effects of Coleus forskohlii on fat storage in ovariectomized rats.Hayashida, N., Chihara, S., Tayama, E., Takaseya, T., Enomoto, N., Kawara, T., and Aoyagi, S. Antiinflammatory effects of colforsin daropate hydrochloride, a novel water-soluble forskolin derivative.Lebedinsky, Y., Nordstrom, S. T., Aschoff, S. E., Kapples, J. F., O'Malley, G. J., Kosley, R.
W., Jr., Fielding, S., and Hubbard, J. W.
Cardiotonic and coronary vasodilator responses to milrinone, forskolin, and analog P87-7692 in the anesthetized dog.A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release.Lichey, I., Friedrich, T., Priesnitz, M., Biamino, G., Usinger, P., and Huckauf, H. Effect of forskolin on methacholine-induced bronchoconstriction in extrinsic asthmatics.Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K.
Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin.Marone, G., Columbo, M., Triggiani, M., Cirillo, R., Genovese, A., and Formisano, S. Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin.Matsumoto, S., Yamashita, T., Araie, M., Kametani, S., Hosokawa, T., and Takase, M. The ocular penetration of topical forskolin and its effects on intraocular pressure, aqueous flow rate and cyclic AMP level in the rabbit eye.Mulhall, J.
P., Daller, M., Traish, A. M., Gupta, S., Park, K., Salimpour, P., Payton, T. R., Krane, R.
J., and Goldstein, I. Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy.Pieske, B., Trost, S., Schutt, K., Minami, K., Just, H., and Hasenfuss, G. Influence of forskolin on the force-frequency behavior in nonfailing and end-stage failing human myocardium.Sashidhara, K. V., Rosaiah, J. N., Kumar, A., Bid, H. K., Konwar, R., and Chattopadhyay, N.
Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro.Undem, B. J. and Buckner, C.
K. Effects of forskolin alone and in combination with isoproterenol on antigen-induced histamine release from guinea-pig minced lung.van Hecke, E., Hindryckx, P., Geuns, J.
M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife.Wajima, Z., Shiga, T., Yoshikawa, T., Ogura, A., Imanaga, K., Inoue, T., and Ogawa, R.
Effect of prophylactic bronchodilator treatment with intravenous colforsin daropate, a water-soluble forskolin derivative, on airway resistance after tracheal intubation.Wong, S., Mok, W., Phaneuf, S., Katz, S., and Salari, H. Forskolin inhibits platelet-activating factor binding to platelet receptors independently of adenylyl cyclase activation.Yanagihara, H., Sakata, R., Shoyama, Y., and Murakami, H. Rapid analysis of small samples containing forskolin using monoclonal antibodies.Yang, Q.
R., Wu, H. Z., Wang, X. M., Zou, G.
A., and Liu, Y. W. Three new diterpenoids from Coleus forskohlii Briq.Zeng, S., Shen, B., Wen, L., Hu, B., Peng, D., Chen, X., and Zhou, W. Experimental studies of the effect of Forskolin on the lowering of intraocular pressure.Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep.Almeida, F.
C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats.Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma.Baumann G, Felix S, Sattelberger U, Klein G.
Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy.Brubaker RF, Carlson KH, Kullerstrand LJ, et al. Topical forskolin (colforsin) and aqueous flow in humans.Burstein NL, Sears ML, Mead A.
Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator.Caprioli J, Sears M, Bausher L, et al. Forskolin lowers intraocular pressure by reducing aqueous inflow.Caprioli J, Sears M.
Forskolin lowers intraocular pressure in rabbits, monkeys, and man.Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.González-Sánchez R, Trujillo X, Trujillo-Hernández B, et al. Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trial.Huerta M, Urzúa Z, Trujillo X, et al.
Forskolin compared with beclomethasone for prevention of asthma attacks: a single-blind clinical trial.Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy.Kreutner W, Chapman RW, Gulbenkian A, Tozzi S. Bronchodilator and antiallergy activity of forskolin.Loftus HL, Astell KJ, Mathai ML, et al.
Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial.Mutolo MG, Albanese G, Rusciano D, Pescosolido N. Oral administration of forskolin, homotaurine, carnosine, and folic acid in patients with primary open angle glaucoma: changes in intraocular pressure, pattern electroretinogram amplitude, and foveal sensitivity.Nebbioso M, Belcaro G, Librando A, et al.
Forskolin and rutin prevent intraocular pressure spikes after Nd:YAG laser iridotomy.Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial.Nishijima C, Chiba T, Sato Y, Umegaki K. Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies.Inhibition of hepatic metastasis from a human pancreatic adenocarcinoma (RWP-2) in the nude mouse by prostacyclin, forskolin, and ketoconazole.Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy.Yokotani K, Chiba T, Sato Y, et al.
Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. .
5 Health Benefits of the Coleus Plant
The coleus plant, a member of the mint family, is popular for its use in gardening due to its brightly colored leaves of green and purple.The root is rich in forskolin, a compound that increases the activity of cyclic adenosine monophosphate (cAMP), a messenger molecule that helps regulate the metabolism of glucose, proteins, and lipids, as well as the function of hormones like adrenaline. Researchers of one study concluded that if patients are administered this natural treatment as soon as hypertension is detected, “then the unnecessary use of powerful synthetic drugs, causing a number of adverse effects, can be effectively avoided.” Studies have also shown that forskolin inhibits platelet aggregation, which has additional benefits on cardiovascular health. cAMP also increases the basal metabolic rate and affects other processes that can influence appetite and energy use in the body. A study in rats with diet-induced obesity found that treatment with coleus extract led to normalization of blood lipid levels, with a decrease in LDL-cholesterol and triglycerides, as well as an increase in HDL-cholesterol. Additionally, while more research is needed in humans, initial trials suggest that coleus is safe and effective for losing weight and body fat.Forskolin found in the coleus plant can lower intraocular pressure by activation of cAMP and reduction in the flow of liquid into the eye. Human studies have shown that a topical application of coleus to the eye effectively lowers intraocular pressure.Coleus may also be beneficial in protecting against cancer metastasis, raising thyroid levels in hypothyroidisim, reducing symptoms of psoriasis, and helping to treat asthma and allergies.Coleus forskohlii is the most commonly used species of this plant used medicinally, so look for a high quality supplement with this latin name on the label. .
How to Create a Shade Garden with Coleus
Flowering plants common to sun gardens depend on abundant light for colorful blooms.Coleus foliage runs from small, dainty scallops to large, ruffled and quilted leaves.The texture of coleus brings shade gardens richness and beauty: leaves pair dazzling colors, such as lime green, fuchsia or neon purple, with deep shades of chocolate, burgundy or red in boundless patterns and combinations.The reptilian Coleusaurus coleus has every leaf crevice in bright burgundy and every high point in lime green.Too much sun or intense midday rays leave foliage scorched and faded; too little light causes weak growth.Too much fertilizer diminishes vibrancy, but low-level organic nutrients reward shade gardeners with outstanding coleus color.Alaska Fish Fertilizer 5-1-1, listed by the Organic Materials Review Institute (OMRI), combines low phosphorus and potassium with a high level of nitrogen to enhance foliage growth and color. .
Coleus: Plant Care & Growing Guide
Common Name Coleus Botanical Name Plectranthus scutellarioides Family Lamiaceae Plant Type Herbacious perennial (usually grown as an annual) Mature Size 6-36 in.tall and wide Sun Exposure Part shade to full shade Soil Type Rich, moist, loose soil Soil pH Slightly acidic to neutral (6.0 to 7.0) Bloom Time Seasonal Flower Color Blue to white Hardiness Zones 10-11 (USDA); grown as an annual everywhere Native Area Asia Toxicity Toxic to animals.In cooler areas with shorter seasons, the shade coleus will need more sun exposure to help them warm up.Plants grown in containers indoors usually get plenty of light from indirect sun during the warmer (brighter) months but may need to be exposed to filtered sunlight during the winter.Container-grown coleus loves the loose texture of potting soil, and it always helps to start with a quality mix with a slightly acidic to neutral pH of 6.0 to 7.0.Provide drainage in the pot to ensure the soil isn't constantly wet, which leads to root rot.The soil should not remain wet all the time, but long dry spells will slow the plants’ growth, and the leaves will start to turn brown around the edges.To take potted plants outdoors in spring, wait until the temperature is 70 degrees Fahrenheit or warmer.If you have poor soil, give the plants a monthly feeding with a balanced fertilizer mixed at half strength.Additional cultivars are developed each year, and garden centers tend to focus on a select few that have proven to be most popular among their customers.Kong series : These coleus varieties have huge 6-inch leaves on big 2-foot tall plants.Plants that are not pruned tend to get leggy and lose their nice shape and dense foliage.This is most common with indoor plants during winter so give them a bit more sun or, if necessary, artificial light.Favorite coleus plants can easily be propagated by taking stem cuttings and rooting them.Dip the end of the stem in a rooting hormone compound, then plant it in a moist potting mix so the soil covers the exposed leaf nodes.Place the covered cutting in a bright, warm location until new roots develop, which will take two to three weeks.Some of the more unusual cultivars might be reluctant to root, so with these, take plenty of cuttings to ensure that you get enough viable plants.If you will be planting the coleus in the outdoor garden, start seeds indoors about eight to 10 weeks before your last frost date.Once seedlings appear, it will take three or four weeks of warm weather to help turn them into fully grown plants.Cover the tray with plastic and set it in a bright, warm spot until seedlings sprout, which takes about two weeks.When two sets of true leaves appear on the seedlings, carefully transplant them into their own pots and continue growing them until outdoor planting time.Coleus quickly grows to full size, potentially up to 36 inches high, in a single season. .
All About Growing Coleus
By selecting from the three different categories, I can find the right coleus plants to balance my container designs.Sometimes I plant pots with nothing but coleus, trusting their contrasting textures and colors to provide plenty of excitement.Trailers soften edges Trailing coleus tend to have leaves that are only an inch long, and the plants typically grow 12 to 18 inches tall.‘Meandering Linda’, a close cousin of ‘Red Trailing Queen’, grows 16 inches tall and bears crinkly, chocolate-purple leaves banded in rich raspberry-pink, with touches of cream along the edges.‘Meandering Linda’ appears to be a sport of ‘Red Trailing Queen’, and if planted in less than half-day sun, it sometimes reverts to its plain burgundy form.‘Trailing Salamander’, which grows 14 inches tall, offers oval, near-black leaves edged in bright lime.Like ‘Red Trailing Queen’, it looks good with almost anything.If a red coleus suits your color scheme, you have to try ‘Ruby Ruffles’, whose frilly, fingery foliage bears ruby centers and chartreuse edges, a color scheme many daylilies echo.Planting 12-inch-tall ‘Ruby Ruffles’ with gold-variegated pigeonberry (Duranta erecta ‘Golden Edge’, Zones 9–11) and deep red Texas sage (Salvia coccinea ‘Spanish Dancer’, Zones 9–11) also makes for a winning tropical combo.Create a starkly dramatic composition by contrasting its color-saturated foliage with white flowers or silver foliage.Four-foot-tall Salvia vanhouttei (Zones 10–11) looks magnificent dangling its burgundy blossoms over 24-inch-tall ‘Swallowtail’. .
Forskolin (Coleus Forskohlii): Generic, Uses, Side Effects, Dosage
What Other Drugs Interact with Forskolin?If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. .
Forskolin: Benefits, Side Effects, Dosage, Interactions
The primary function of AC-III is to facilitate the transfer of chemical messages from the outside of the cell to the inside of a cell.At the end of the 12-week study, men who took forskolin achieved greater losses in body fat and increases in lean muscle mass compared to the placebo group.A 2013 study from Italy reported that a supplement containing forskolin and the flavonoid called rutin reduced inner eye pressure by 10% in people with glaucoma after 30 days. Higher doses corresponded to greater decreases in eye pressure.A similar study from Mexico reported that a 10-milligram daily dose of forskolin compared favorably to twice-daily inhalations of the asthma drug Qvar (beclomethasone) in reducing the number of asthma attacks..Where forskolin underperformed was in its ability to improve respiratory function (as measured by the FEV1).Forskolin supplements do not appear to be harmful, although their long-term safety has yet to be established.Some people may experience side effects after taking forskolin, including low blood pressure, slow heart rate, and diarrhea..High blood pressure medications, including beta-blockers and calcium channel blockers.Can you get forskolin from coleus plants?While forskolin is derived from the Indian coleus plant, there is no evidence that consuming the coleus offers any health benefits. .